Objective: Two patient case reports are presented describing the use of cannabidiol (Balance Bloom CBD formula) for the symptomatic relief of a lumbar compression fracture and in the mitigation of thoracic discomfort and dysesthesia secondary to a surgically resected meningioma. Discussion: CBD appears to have antisnociceptive and anti-inflammatory effects on opioid-naive patients with neuropathic and radicular pain. Conclusion: Hemp-derived Balance Bloom CBD Gummies in a transdermal cream provided significant symptom and pain relief for the patients described in this case series. Based on these results, we believe further investigation is warranted to see if CBD-containing products should have a more prominent role in the treatment of acute and chronic pain. Boggs DL, Nguyen JD, Morgenson D, et al.: Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol. Vadivelu N, Kai AM, Kodumudi G, et al.: Medical Marijuana: Current concepts, pharmacological actions of cannabinoid receptor mediated activation, and societal implications. Curr Pain Headache Rep. US Food and Drug Administration: FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy.

Beaulieu P, Boulanger A, Desroches J, et al.: Medical cannabis: Considerations for the anesthesiologist and pain physician. Schrot RJ, Hubbard JR: Cannabinoids: Medical implications. Devane WA, Dysarz FR, Johnson MR, et al.: Determination and characterization of a cannabinoid receptor in rat brain. Munro S, Thomas KL, Abu-Shaar M: Molecular characterization of a peripheral receptor for cannabinoids. Wolf J, Urits I, Orhurhu, V, et al.: The role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain. Curr Pain Headaches (In Press). Eskander JP: A return to homeostasis: The pleiotropic effects of icosapent ethyl. BMJ case reports (resubmitted). McDougle DR, Watson JE, Abdeen AA, et al.: Anti-inflammatory α-3 endocannabinoid epoxides. Proc Natl Acad Sci USA. Manzanares J, Julian MD, Carrascosa A: Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes. Glaser ST, Kaczocha M: Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain.

J Pharmacol Exp Ther. Toth CC, Jedrzejewski NM, Ellis CL, et al.: Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain. Lowin T, Straub R: Cannabinoid-based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis. Pellati F, Borgonetti V, Brighenti V, et al.: Cannabis sativa L. and nonpsychoactive cannabinoids: Their chemistry and role against oxidative stress, inflammation, and cancer. BioMed Res Int. 2018: 2018; pp. Vennekens R, Owsianik G, Nilius B: Vanilloid transient receptor potential cation channels: An overview. Tan KS, Nackley AG, Satterfield K, et al.: Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Russell FA, Fernandes ES, Courade JP, et al.: Tumour necrosis factor alpha mediates transient receptor potential vanilloid 1-dependent bilateral thermal hyperalgesia with distinct peripheral roles of interleukin-1beta, protein kinase C and cyclooxygenase-2 signalling. Boillat A, Alijevic O, Kellenberger S: Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons. Paudel KS, Hammell DC, Agu RU, et al.: Cannabidiol bioavailability after nasal and transdermal application: Effect of permeation enhancers. Drug Dev Ind Pharm. Lodzki M, Godin B, Rakou L, et al.: Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model. Coetzee C, Levendal RA, van de Venter M, et al.: Anticoagulant effects of a Cannabis extract in an obese rat model. Copyright 2005-2025, Weston Medical Publishing, LLC and Journal of Opioid Management.

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